References & Help
What’s New?
- Update 6/19/25 Version 1.0.2 – Fixed a minor issue to show recommendation when to re-dose the next regimen if AUC is > 600
- Update 6/13/25 Version 1.0.1 – Added recommendation when to re-dose for the next regimen when AUC24 is > 600
- Would recommend to re-dose when estimated vancomycin level is approaching approximately 15 mg/L
How to Use
- Input all the data required
- Click Calculate to generate parameters and kinetic model
- Recommended dose/frequency is based on AUC 400–600 mg·hr/L
- Enter your desired dose and frequency, select the preferred ke model, then click Generate to finalize the patient plan Note: For Actual ke calculations, the volume of distribution (Vd) is retained while the elimination rate constant (ke) is adjusted to match the specific time the trough was drawn. This allows the model to more accurately reflect the patient’s observed level, resulting in a more individualized pharmacokinetic profile.
Formulas Used
Vd = (0.29 × Age) + (0.33 × Weight) + 11ke (Single-Point) = -ln((Ctrough × Vd / Dose) ÷ [1 + (Ctrough × Vd / Dose)]) ÷ Tke = ((0.705 × CrCl + 4) × 0.06) / VdHalf-life = 0.693 / keCmax = [Dose / (t' × ke × Vd)] × [(1 - e−ke × t') ÷ (1 - e−ke × τ)]Cmin = Cmax × e−ke × (τ − t')AUC24 = (Dose / (Vd × ke)) × (24 / τ)Alternative AUC24 Checks = [(Cmax + Ctrough)/2 × (Dose/1000)] + [(Cmax − Ctrough) / ke]Custom Trough Goal = (400–600 × Trough) ÷ AUC24
References
-
IDSA 2020 Guidelines – AUC-based dosing.
https://pubmed.ncbi.nlm.nih.gov/32227354/ -
Fewel N. – Trough-only AUC Estimation.
https://pubmed.ncbi.nlm.nih.gov/36477193/ -
Murphy, J.E. Clinical Pharmacokinetics, 7th Edition & Workbook.
https://www.amazon.com/Clinical-Pharmacokinetics-Workbook/dp/1585287008
Disclaimer:
This tool is provided by GuideRPH for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. All calculations should be independently verified, and clinical decisions should be based on professional judgment, official guidelines, and the individual patient’s needs. GuideRPH assumes no responsibility or liability for any errors, inaccuracies, or outcomes resulting from the use of this tool. By using this tool, you acknowledge and agree that it is to be used as a reference only and that you are solely responsible for any clinical decisions you make. This tool may not reflect the latest medical research or standards, and the user is responsible for consulting up-to-date sources.
This tool is provided by GuideRPH for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. All calculations should be independently verified, and clinical decisions should be based on professional judgment, official guidelines, and the individual patient’s needs. GuideRPH assumes no responsibility or liability for any errors, inaccuracies, or outcomes resulting from the use of this tool. By using this tool, you acknowledge and agree that it is to be used as a reference only and that you are solely responsible for any clinical decisions you make. This tool may not reflect the latest medical research or standards, and the user is responsible for consulting up-to-date sources.