References & Help
How to Use
- Input all required patient, dosing, and level data
- Choose the correct order of timing (Peak → Trough or Trough → Peak)
- Click Calculate to generate PK parameters and AUC model
- Adjust dose/frequency manually or choose from the suggested regimens based on AUC24 400–600 mg·hr/L
- Click Calculate under Manual Adjustment to generate a patient plan
Formulas Used
ke = ln(C1 / C2) / Δt(Elimination rate constant using two levels)Half-life = 0.693 / keCmax = Measured Peak ÷ (e−ke × Δt)Cmin = Cmax × e−ke × (τ − t’)Vd = Dose × (1 - e−ke × t’) / [ t’ × ke × (Cmax − Cmin × e−ke × t’) ]CL = ke × VdAUC24 = (((Cmax + Cmin)/2) × t') + ((Cmax − Cmin) / ke) × (24 / τ)Custom Trough Goal = (400–600 × Estimated Trough) ÷ AUC24
References
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IDSA 2020 Guidelines – AUC-based vancomycin monitoring and two-level AUC preferred over trough-only.
https://pubmed.ncbi.nlm.nih.gov/32227354/ -
Murphy JE. Clinical Pharmacokinetics, 7th Edition & Workbook. ASHP, 2022.
https://www.amazon.com/Clinical-Pharmacokinetics-Workbook/dp/1585287008
Disclaimer:
This tool is provided by GuideRPH for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. All calculations should be independently verified, and clinical decisions should be based on professional judgment, official guidelines, and the individual patient’s needs. GuideRPH assumes no responsibility or liability for any errors, inaccuracies, or outcomes resulting from the use of this tool. By using this tool, you acknowledge and agree that it is to be used as a reference only and that you are solely responsible for any clinical decisions you make. This tool may not reflect the latest medical research or standards, and the user is responsible for consulting up-to-date sources.
This tool is provided by GuideRPH for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. All calculations should be independently verified, and clinical decisions should be based on professional judgment, official guidelines, and the individual patient’s needs. GuideRPH assumes no responsibility or liability for any errors, inaccuracies, or outcomes resulting from the use of this tool. By using this tool, you acknowledge and agree that it is to be used as a reference only and that you are solely responsible for any clinical decisions you make. This tool may not reflect the latest medical research or standards, and the user is responsible for consulting up-to-date sources.